by michaelhalassa | Sep 14, 2025 | ADHD medication and psychosis, Algorithmic psychiatry, Chronic stimulant use, Computational psychiatry, Distributed neural systems, Dopamine and psychosis, Healthcare, Mental health treatment, Michael Halassa, Predictive systems, Psychiatry, Reward-seeking systems, Stimulant side effects, Stimulant-induced psychosis
The Portal in the Basement The EMTs who brought Stephanie to the inpatient unit looked genuinely unsettled. She’d been found at 3 AM, methodically photographing her neighbors’ houses with her phone, documenting what she described as “dimensional...
by michaelhalassa | Aug 18, 2025 | Algorithmic psychiatry, Computational psychiatry, Dopamine and psychosis
There’s a paradox at the heart of modern psychiatry that keeps me up at night. We have two ways of understanding mental illness that seem fundamentally at odds, yet both appear indispensable. On one side, we have the molecular story: dopamine receptors,...
by michaelhalassa | Jul 16, 2025 | Cobenfy, Algorithmic psychiatry, Computational psychiatry, Distributed neural systems, Dopamine and psychosis, KarXT, Mental health treatment, Michael Halassa, muscarinic antipsychotic, Schizophrenia treatment, Xanomeline
I had the privilege of attending and in part organizing the inaugural Innovation in Psychosis Therapeutics Summit in Boston (June 9-11, 2025). This intimate gathering brought together scientists, clinicians and biotech leaders who share a common goal: to finally push...
by | Mar 25, 2025 | ADHD medication and psychosis, Chronic stimulant use, Dopamine and psychosis, Stimulant side effects, Stimulant-induced psychosis
Chronic Stimulant Use and Psychosis: Mildred’s Story and the Science Behind the Link Mildred’s Story: A Surprising Onset of Psychosis Mildred, a middle-aged woman in her late 50s, had always been the picture of health—both physically and mentally. With no personal or...
